Insights from ME/CFS May Help Unravel the Pathogenesis of Post-Acute COVID-19 Syndrome

New paper by: Anthony L. Komaroff 1 and W. Ian Lipkin 2 1 Division of General Medicine, Department of Medicine, Brigham and Women’sHospital, Harvard Medical School, Boston, MA2 Center for Infection and Immunity, Mailman School of Public Health, ColumbiaUniversity, New York, NY Available here from 7 June 2021 Journal Pre-proofDOI: https://doi.org/10.1016/j.molmed.2021.06.002 Citation: A.L. Komaroff andContinue reading “Insights from ME/CFS May Help Unravel the Pathogenesis of Post-Acute COVID-19 Syndrome”

Myalgic encephalomyelitis/ chronic fatigue syndrome as a breakdown of homeostasis

David F Marks published on 31 May 2021 here Abstract Homeostasis is a fundamental physiological principle that ensures equilibrium, stability and safety of the organism in a continuously changing and potentially life-threatening environment. This article introduces a new theory of the aetiology of ME/CFS that hypothesises that ME/CFS is caused by a breakdown of homeostasisContinue reading “Myalgic encephalomyelitis/ chronic fatigue syndrome as a breakdown of homeostasis”

Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS

HYPOTHESIS AND THEORY ARTICLE Front. Med., 28 January 2021 | https://doi.org/10.3389/fmed.2021.62802 Dominic Stanculescu, Lars Larsson and Jonas Bergquist Under a Creative Commons license open access Here Dominic Stanculescu et al. advance the hypothesis that ‘maladaptive mechanisms’ that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these mechanisms are: (a) suppression ofContinue reading “Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS”

MECFS: evidence for an autoimmune disease

Autoimmunity Reviews Volume 17, Issue 6, June 2018, Pages 601-609 Review: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease Franziska Sotzny et al., on behalf of the European Network on ME/CFS (EUROMEN) https://doi.org/10.1016/j.autrev.2018.01.009 Under a Creative Commons license open access Highlights The pathogenesis of ME/CFS is multifactorial, and immunological and environmental factors play a role.•Continue reading “MECFS: evidence for an autoimmune disease”

ME/CFS and autoimmunity

The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs) Gerwyn Morris,  Michael Berk,  Piotr Galecki &  Michael Maes  Molecular Neurobiology volume 49, pages741–756(2014) Cite this article Abstract The World Health Organization classifies myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs) as a nervous system disease. Together with other diseases under the G93 heading, ME/cfs shares a triad of abnormalities involvingContinue reading “ME/CFS and autoimmunity”

ME/CFS as a Breakdown in Homeostasis

Here I present a new theory of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disabling and complex illness affecting millions of people worldwide. The Centers for Disease Control and Prevention (CDC) defines ME/CFS as follows: People with ME/CFS are often not able to do their usual activities. At times, ME/CFS may confine them to bed. PeopleContinue reading “ME/CFS as a Breakdown in Homeostasis”

Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease

Anel, A., Gallego-Lleyda, A., de Miguel, D., Naval, J., & Martínez-Lostao, L. (2019). Role of exosomes in the regulation of T-cell mediated immune responses and in autoimmune disease. Cells, 8(2), 154. Abstract T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate thisContinue reading “Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease”

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

Van Parijs, L., & Abbas, A. K. (1998). Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science, 280(5361), 243-248. Abstract The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system toContinue reading “Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off”